New non sedating antihistamines

In addition, if you have liver or kidney disease you may need a lower dose of these medicines, though this depends on the particular medicine prescribed.

Some antihistamines may also be helpful in reducing anxiety, inducing sleep, or at preventing or treating motion sickness.Antihistamines are a class of agents that block histamine release from histamine-1 receptors and are used to treat the symptoms of an allergic reaction, such as edema (swelling), itch, inflammation (redness), sneezing, or a runny nose or watery eyes.Antihistamines can be further divided into those unlikely to cause drowsiness (non-sedating antihistamines) or those likely to cause drowsiness (sedating antihistamines).The present invention is related to l-[(4-chlorophenyl)-phenylmethyl]-4-(2,2,2-trichloroethoxycarbonyl)-piperazine of the Formula (IV) and optically isomers thereof, process for preparation thereof and the use of the compound of the Formula (IV) in the preparation of l-(4-chlorophenyl)-phenylmethyl-piperazine and optical isomers and salts thereof.l-(4-chlorophenyl)-phenylmethyl-piperazine and optical isomers thereof are important intermediates in the preparation of The present invention discloses uses of fluorinated descarboethoxyloratadine (' FDCL', Formula A) represented by formula (III), for preparation of medicaments for the treatment of allergic rhinitis and other allergies, including asthma, while avoiding the concomitant liability of adverse side-effects associated with other in combination with an $g(a)-adrenergic agonist and optionally conventional physiologically acceptable carriers, diluting agents and auxiliaries substances for the prophylaxis and treatment of allergic and/or vasomotoric rhinitis, conjunctivitis, cold, cold-like and/or flu symptoms are claimed.The most commonly used ones are promethazine (Phenergan), hydroxyzine (Atarax), or alimemazine (Vallergan).

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